Micro-nanoplastics are emerging as a novel risk factor for cardiovascular disease due to their ability to induce oxidative stress, inflammation, and endothelial dysfunction. As the prevalence of MNPs in the environment increases, understanding their full impact on cardiovascular health is crucial for developing preventative strategies.
In humans, MNPs have been detected in atherosclerotic plaques and epicardial adipose tissue, pericardial adipose tissue, myocardial, left atrial appendages. The chemical exposome is increasingly recognized as a possible driver of CVD.Given the substantial residual environmental risk despite proper control of multiple risk factors, increasing levels of chemical exposures have been hypothesized as being relevant. While solid mechanistic and epidemiological evidence support many external pollutants, such as air pollution and some chemical exposures, there remain substantial gaps with plastics and related chemicals. The production and the improper disposal of plastic waste are held to impact human health at multiple levels. Plasticizer chemicals have already been linked to a range of cardiometabolic diseases,and plastic production can also affect human health and CVD development through multiple indirect routes.
Main article link: https://academic.oup.com/eurheartj/advancearticle/doi/10.1093/eurheartj/ehae552/7750375?login=false
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