Conclusion: Compared to those of normal weight, obese people have a 50%–100% higher chance of dying from all causes, with cardiovascular disease accounting for the majority of this increased risk. Reliance on novel pharmacotherapies for the treatment of established obesity as opposed to ongoing efforts for obesity prevention based on sustainable healthy lifestyle changes represents a significant advancement in the field of managing patients with obesity, as evidenced by the recent development of weight loss medications with established cardiovascular benefits.