# CRM Academy

> Advancing Care in Cardiology, Renal, and Metabolism


## Posts

- [CRM Fun Quiz #22](https://crmacademy.co.uk/crm-fun-quiz-21/)
- [CRM Fun Quiz #21](https://crmacademy.co.uk/crm-fun-quiz-21-2/)
- [CRM Fun Quiz #20](https://crmacademy.co.uk/crm-fun-quiz-20/)
- [CRM Fun Quiz #19](https://crmacademy.co.uk/crm-fun-quiz-19/)
- [CRM Fun Quiz #18](https://crmacademy.co.uk/crm-fun-quiz-18/)
- [CRM Fun Quiz #17](https://crmacademy.co.uk/crm-fun-quiz-17/)
- [CRM Fun Quiz #16](https://crmacademy.co.uk/crm-fun-quiz-14/)
- [CRM Fun Quiz #15](https://crmacademy.co.uk/crm-fun-quiz-15/)
- [CRM Fun Quiz #14](https://crmacademy.co.uk/crm-fun-quiz-14-2/)
- [Is SGLT2i better than GLP-1RA for preservation of renal function in T2D?](https://crmacademy.co.uk/is-sglt2i-better-than-glp-1ra-for-preservation-of-renal-function-in-t2d/): YES! SGLT2i is better than GLP-1RA for preservation of renal function in Type 2 Diabetes. In individuals with type 2 diabetes, treatment with SGLT2i was associated with better preservation of renal function compared with GLP-1RA, as evidenced by slower decline in eGFR. These findings reinforce SGLT2i as preferred agents for renal protection in this patient […]
- [Can Micro-nanoplastics Cause Cardiovascular Diseases?](https://crmacademy.co.uk/can-micro-nanoplastics-cause-cardiovascular-diseases/): Micro-nanoplastics are emerging as a novel risk factor for cardiovascular disease due to their ability to induce oxidative stress, inflammation, and endothelial dysfunction. As the prevalence of MNPs in the environment increases, understanding their full impact on cardiovascular health is crucial for developing preventative strategies. In humans, MNPs have been detected in atherosclerotic plaques and […]
- [Obesity is a major risk factor for cardiovascular diseases: An ESC clinical consensus statement.](https://crmacademy.co.uk/obesity-is-a-major-risk-factor-for-cardiovascular-diseases-an-esc-clinical-consensus-statement/): Conclusion: Compared to those of normal weight, obese people have a 50%–100% higher chance of dying from all causes, with cardiovascular disease accounting for the majority of this increased risk. Reliance on novel pharmacotherapies for the treatment of established obesity as opposed to ongoing efforts for obesity prevention based on sustainable healthy lifestyle changes represents […]
- [Finerenone can lower the rate of worsening heart failure events and deaths from cardiovascular causes in patients with mildly reduced or preserved ejection fraction.](https://crmacademy.co.uk/finerenone-can-lower-the-rate-of-worsening-heart-failure-events-and-deaths-from-cardiovascular-causes-in-patients-with-mildly-reduced-or-preserved-ejection-fraction/): Conclusion: In patients with heart failure and mildly reduced or preserved ejection fraction, finerenone resulted in a significantly lower rate of a composite of total worsening heart failure events and death from cardiovascular causes than placebo. Finerenone caused 16% reduction in RR primary endpoint like cardiovascular deaths and worsening of heart failure. 12% reduction in […]
- [FLOW: Semaglutide provides consistent CV benefits across the spectrum of kidney disease.](https://crmacademy.co.uk/flow-semaglutide-provides-consistent-cv-benefits-across-the-spectrum-of-kidney-disease/): Conclusion: Semaglutide reduced CV Deaths/MI/Stroke by 18% with consistency across eGFR categories, uACR levels & KIDGO risk classification. Semaglutidereduced the risk of clinically important kidney outcomes and death from cardiovascular causes in patients with type 2 diabetes and chronic kidney disease. Read full abstract
- [Treatment with SGLT2i after Myocardial Infarction in patients with Type 2 Diabetes is associated with lower rate of cardiovascular events.](https://crmacademy.co.uk/treatment-with-sglt2i-after-myocardial-infarction-in-patients-with-type-2-diabetes-is-associated-with-lower-rate-of-cardiovascular-events/): Conclusion: In an observational study in patients with type 2 diabetes with acute myocardial infarction, it was found that SGTL2 inhibitor treatment was associated with lower rates of first hospitalisation for heart failure and all-cause death. During the one year of follow-up, treatment with SGLT2 inhibitors was associated with a 30% lowered hazard ratio of […]
- [SGLT2i can lower the risk of dementia in patients with Type 2 Diabetes when compared with DPP4 inhibitors](https://crmacademy.co.uk/sglt2i-can-lower-the-risk-of-dementia-in-patients-with-type-2-diabetes-when-compared-with-dpp4-inhibitors/): Conclusion: A large population based cohort study among people with type 2 diabetes aged 40-69 years found a 35% lower risk of dementia associated with use of SGLT-2 inhibitors compared with DPP-4 inhibitors. This finding persisted regardless of dementia type and across subgroups of diverse population characteristics such as age, sex, concomitant use of metformin, […]
- [CRM Fun Quiz #13](https://crmacademy.co.uk/crm-fun-quiz-13/)
- [CRM Fun Quiz #12](https://crmacademy.co.uk/crm-fun-quiz-12/)
- [CRM Fun Quiz #11](https://crmacademy.co.uk/crm-fun-quiz-11/)
- [CRM Fun Quiz #10](https://crmacademy.co.uk/crm-fun-quiz-10/)
- [CRM Fun Quiz #9](https://crmacademy.co.uk/crm-fun-quiz-9/)
- [CRM Fun Quiz #8](https://crmacademy.co.uk/crm-fun-quiz-8/)
- [CRM Fun Quiz #7](https://crmacademy.co.uk/crm-fun-quiz-7/)
- [CRM Fun Quiz #6](https://crmacademy.co.uk/crm-fun-quiz-6/)
- [CRM Fun Quiz #5](https://crmacademy.co.uk/crm-fun-quiz-5/)
- [Is there any association between HDL-C/HDL-P & increased overall risk of Heart Failure?](https://crmacademy.co.uk/is-there-any-association-between-hdl-c-hdl-p-increased-overall-risk-of-heart-failure/): Introduction High-density lipoprotein (HDL) is commonly characterized by its cholesterol concentration (HDL-C) and inverse association with atherosclerotic cardiovascular disease. Results Higher HDL-P was associated with a lower risk of HF. In contrast, larger HDL-size was associated with higher risk of HF and there was no significant association observed between HDL-C and HF risk after accounting […]
- [Can smartphones identify patients with  Heart Failure?](https://crmacademy.co.uk/can-smartphones-identify-patients-with-heart-failure/): Introduction The most common reason for hospitalization in those over 65 is heart failure (HF). Finding non-invasive ways to identify HF might help stop the HF pandemic. Recently, seismocardiography — a technique that monitors cardiac vibrations conveyed to thechest wall—has become a potential tool for the detection of heart failure. Results Smartphone-based assessment of cardiac […]
- [CRM Fun Quiz #4](https://crmacademy.co.uk/crm-fun-quiz-4/)
- [CRM Fun Quiz #3](https://crmacademy.co.uk/crm-fun-quiz-2-2/)
- [CRM Fun Quiz #2](https://crmacademy.co.uk/crm-fun-quiz-2/)
- [CRM Fun Quiz #1](https://crmacademy.co.uk/crm-quiz/)
- [Recommendation for revascularisation in patients with diabetes](https://crmacademy.co.uk/recommendation-for-revascularisation-in-patients-with-diabetes/)
- [Recommendations for a multifactorial approach in patients with type 2 diabetes with and without cardiovascular disease](https://crmacademy.co.uk/recommendations-for-a-multifactorial-approach-in-patients-with-type-2-diabetes-with-and-without-cardiovascular-disease/)
- [Recommendation for multifactorial approach to risk factors management in diabetes](https://crmacademy.co.uk/recommendation-for-multifactorial-approach-to-risk-factors-management-in-diabetes/)
- [Antithrombotic therapy and diabetes](https://crmacademy.co.uk/antithrombotic-therapy-and-diabetes/): Recommendation for patients with diabetes without a history of symptomatic atherosclerotic cardiovascular disease or revascularisation Recommendation for antiplatelet therapy in patients with diabetes with acute or chronic coronary syndrome undergoing percutaneous coronary intervention Recommendation for antithrombotic therapy in patients with diabetes and acute or chronic coronary syndrome without indications for long term anti-coagulation Recommendation for […]
- [Recommendation for the management of dyslipidaemia in patients with diabetes](https://crmacademy.co.uk/recommendation-for-the-management-of-dyslipidaemia-in-patients-with-diabetes/)
- [Recommendation for blood pressure management in patients with diabetes](https://crmacademy.co.uk/recommendation-for-blood-pressure-management-in-patients-with-diabetes/)
- [Hypertension and Diabetes](https://crmacademy.co.uk/hypertension-and-diabetes/)
- [Recommendation for glucose lowering treatment for patients with T2D and atherosclerotic CVD to reduce CVD risk](https://crmacademy.co.uk/recommendation-for-glucose-lowering-treatment-for-patients-with-t2d-and-atherosclerotic-cvd-to-reduce-cvd-risk/)
- [Glucose lowering treatment for patient with T2D and atherosclerotic cardiovascular disease to reduce cardiovascular risk](https://crmacademy.co.uk/glucose-lowering-treatment-for-patient-with-t2d-and-atherosclerotic-cardiovascular-disease-to-reduce-cardiovascular-risk/)
- [Glucose lowering treatment for patients with T2D to reduce CVD based on the presence of atherosclerotic CVD](https://crmacademy.co.uk/glucose-lowering-treatment-for-patients-with-t2d-to-reduce-cvd-based-on-the-presence-of-atherosclerotic-cvd/)
- [Recommendation for glycaemic targets in patients with Diabetes](https://crmacademy.co.uk/recommendation-for-glycaemic-targets-in-patients-with-diabetes/)
- [Recommended guide to glycaemic targets in patients with T2D and CVD](https://crmacademy.co.uk/recommended-guide-to-glycaemic-targets-in-patients-with-t2d-and-cvd/)
- [Recommendation for smoking cessation in patients with T2D with or without cardiovascular disease](https://crmacademy.co.uk/recommendation-for-smoking-cessation-in-patients-with-t2d-with-or-without-cardiovascular-disease/)
- [Recommendation of physical exercise/activity in patients with T2D with or without CVD](https://crmacademy.co.uk/recommendation-of-physical-exercise-activity-in-patients-with-t2d-with-or-without-cvd/)
- [REVISED CONCEPTS 2023 GUIDELINES ](https://crmacademy.co.uk/revised-concepts-2023-guidelines/)
- [MANAGEMENT OF CARDIOVASCULAR DISEASE IN PATIENTS WITH TYPE 2 DIABETES](https://crmacademy.co.uk/management-of-cardiovascular-disease-in-patients-with-type-2-diabetes/)
- [MANAGEMENT OF AF IN PATIENTS WITH DIABETES](https://crmacademy.co.uk/management-of-af-in-patients-with-diabetes/): Recommendations for AF in patients with diabetes: Recommendation for anticoagulation for AF in patients with diabetes:
- [ESC GUIDELINES FOR TREATMENT OF HF PATIENTS WITH DIABETES](https://crmacademy.co.uk/esc-guidelines-for-treatment-of-hf-patients-with-diabetes/): Recommendations for treatment of HF in patients with HFrEF and diabetes: Recommendations for other treatments indicated in select patients with HFrEF (NYHA class II-IV) and diabetes: Recommendations for glucose-lowering medication in patients with T2DM with and without heart failure: Recommendations for additional glucose-lowering agents with safety demonstrated for HF hospitalization in patients with T2DM if […]
- [Recommendation for nutrition in patients with T2D diabetes with or without CVD](https://crmacademy.co.uk/recommendations-for-reducing-weight-in-patient-with-t2d-with-or-without-cvd-2/)
- [Recommendations for reducing weight in patient with T2D with or without CVD](https://crmacademy.co.uk/recommendations-for-reducing-weight-in-patient-with-t2d-with-or-without-cvd/)
- [Recommendation for assessing Cardiovascular risk in patient with T2D](https://crmacademy.co.uk/recommendation-for-assessing-cardiovascular-risk-in-patient-with-t2d/)
- [SCORE 2- Diabetes: estimating 10 year cardiovascular risk](https://crmacademy.co.uk/score-2-diabetes-estimating-10-year-cardiovascular-risk/)
- [Cardiovascular risk categories in T2D](https://crmacademy.co.uk/cardiovascular-risk-categories-in-t2d/)
- [Recommendation for diagnosing diabetes](https://crmacademy.co.uk/recommendation-for-diagnosing-diabetes/)
- [Recommendations for treatment of HF in patients with HFrEF and diabetes:](https://crmacademy.co.uk/recommendations-for-treatment-of-hf-in-patients-with-hfref-and-diabetes/)
- [Empagliflozin reduces liver fat in individual with or without diabetes.](https://crmacademy.co.uk/empagliflozin-reduces-liver-fat-in-individual-with-or-without-diabetes/): Beyond its primary usage in the treatment of type 2 diabetes, empagliflozin, an inhibitor of sodium-glucose co-transporter 2 (SGLT2), has demonstrated potential advantages in other areas. Recent data suggests that empagliflozin may have a wider function in treating metabolic health conditions such non-alcoholic fatty liver disease (NAFLD) by lowering liver fat content in people with […]
- [Venturing the link between cardio renal metabolic diseases](https://crmacademy.co.uk/venturing-the-link-between-cardio-renal-metabolic-diseases/): Cardio-renal-metabolic (CRM) diseases represent a complex and interconnected spectrum of conditions that encompass cardiovascular diseases (CVDs), renal diseases, and metabolic disorders like diabetes and obesity. The relationship among these conditions is multifaceted and bidirectional, with each disease acting as a risk factor for the others, thereby creating a vicious cycle of morbidity and mortality.  Studies […]
- [Elevated lipoprotein(a) (Lp[a]) concentrations are linked to an increased risk of cardiovascular events](https://crmacademy.co.uk/even-when-low-density-lipoprotein-cholesterol-levels-are-under-strict-control-elevated-lipoproteina-lpa-concentrations-are-linked-to-an-increased-risk-of-cardiovascular-events-however-there-i/): Conclusion: Among patients receiving statin medication and having elevated triglyceride levels, baseline Lp(a) concentration was predictive of MACE. Crucially, MACE was consistently decreased by IPE across a range of Lp(a) values, including those in patients with elevations that were clinically significant. Read full abstract
- [The Global Burden Diseases Data:The 2023 Almanac(1990-2023) calls for compelling urgency for Global Action.](https://crmacademy.co.uk/the-global-burden-diseases-datathe-2023-almanac1990-2023-calls-for-compelling-urgency-for-global-action/): The 5 metabolic risks highlighted are:
- [When patients with heart failure are on SGLT2 inhibition, water conservation takes precedence over osmotic diuresis.](https://crmacademy.co.uk/when-patients-with-heart-failure-are-on-sglt2-inhibition-water-conservation-takes-precedence-over-osmotic-diuresis/): Conclusion: SGLT2i release increase glucose into the urine & thereby have potential to pull more fluid from the body via osmosis into the urine and decongest patient with heart failure Read full abstract
- [Recommended Sodium & Fluid Intake for HF Patients by ESC to be 1-1.5L/day](https://crmacademy.co.uk/recommended-sodium-fluid-intake-for-hf-patients-by-esc-to-be-1-1-5l-day/): Conclusion: All HF patients are advised to refrain from consuming excessive amounts of fluid, according to the 2021 ESC HF recommendations. An average person’s daily fluid consumption typically ranges from 1.5 to 2.5 L, or 15–30 mL/kg. A restricted fluid strategy usually involves an intake of less than 1–1.5 L/day, whereas a more liberal approach […]
- [Administration of metformin before meals may optimize its effects in improving post-prandial glycemic control.](https://crmacademy.co.uk/administration-of-metformin-before-meals-may-optimize-its-effects-in-improving-post-prandial-glycemic-control/): Conclusion: Study reveals that when metformin is administered before to enteral glucose rather than concurrently with it, it lowers blood glucose levels more effectively in type 2 diabetes that is well-controlled on metformin and is linked to a higher GLP-1 response. These findings imply that taking metformin before to meals may maximize its impact on […]
- [The cardio-renal-metabolic connection: a review of the evidence](https://crmacademy.co.uk/the-cardio-renal-metabolic-connection-a-review-of-the-evidence/): Listen to the abstract or read below Abstract Type 2 diabetes (T2D), cardiovascular disease (CVD) and chronic kidney disease (CKD), are recognized among the most disruptive public health issues of the current century. A large body of evidence from epidemiological and clinical research supports the existence of a strong interconnection between these conditions, such that […]
- [Bariatric surgery and cardiovascular disease a systematic review and meta-analysis](https://crmacademy.co.uk/bariatric-surgery-and-cardiovascular-disease-a-systematic-review-and-meta-analysis/)
- [Bone marrow activation in response to metabolic syndrome and early atherosclerosis](https://crmacademy.co.uk/bone-marrow-activation-in-response-to-metabolic-syndrome-and-early-atherosclerosis/)
- [Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes](https://crmacademy.co.uk/cardiovascular-and-renal-outcomes-with-efpeglenatide-in-type-2-diabetes/)
- [Dapagliflozin across the range of ejection fraction in patients with heart failure: a patient-level, pooled meta-analysis of DAPA-HF and DELIVER](https://crmacademy.co.uk/dapagliflozin-across-the-range-of-ejection-fraction-in-patients-with-heart-failure-a-patient-level-pooled-meta-analysis-of-dapa-hf-and-deliver/)
- [Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction](https://crmacademy.co.uk/dapagliflozin-in-heart-failure-with-mildly-reduced-or-preserved-ejection-fraction/)
- [Effects of aspirin on dementia and cognitive function in diabetic patients the ASCEND trial](https://crmacademy.co.uk/effects-of-aspirin-on-dementia-and-cognitive-function-in-diabetic-patients-the-ascend-trial/)
- [Empagliflozin and serum potassium in heart failure: an analysis from EMPEROR-Pooled](https://crmacademy.co.uk/empagliflozin-and-serum-potassium-in-heart-failure-an-analysis-from-emperor-pooled/)
- [Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies](https://crmacademy.co.uk/empagliflozin-in-the-treatment-of-heart-failure-with-reduced-ejection-fraction-in-addition-to-background-therapies/)
- [Polypill for prevention of cardiovascular diseases with focus on non alcoholic steatohepatitis the PolyIran Liver trial](https://crmacademy.co.uk/polypill-for-prevention-of-cardiovascular-diseases-with-focus-on-non-alcoholic-steatohepatitis-the-polyiran-liver-trial/)
- [SGLT2 inhibitors in patients with heart failure: a comprehensive meta analysis of five randomised controlled trials](https://crmacademy.co.uk/sglt2-inhibitors-in-patients-with-heart-failure-a-comprehensive-meta-analysis-of-five-randomised-controlled-trials/)

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